Cajun Chicken Alfredo Pasta

Featured in: Easy Weeknight Meals

This dish features tender chicken breasts seasoned with vibrant Cajun spices, sautéed to golden perfection. It’s combined with fettuccine tossed in a smooth, creamy Velveeta cheese sauce enriched with butter, garlic, and Parmesan. A subtle hint of cayenne adds extra warmth. Garnished with fresh parsley and extra Parmesan, it offers a satisfying meal with a Southern flair that's both easy and delicious to prepare.

Updated on Sun, 23 Nov 2025 11:24:00 GMT
Golden slices of Cajun Chicken Alfredo Fettuccine Pasta are tossed in a creamy, cheesy sauce, ready to serve. Save
Golden slices of Cajun Chicken Alfredo Fettuccine Pasta are tossed in a creamy, cheesy sauce, ready to serve. | ovenharmony.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This recipe quickly became a family favorite after I first served it during a chilly weeknight dinner.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional for extra heat), Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
A close-up view of the rich, enticing Cajun Chicken Alfredo Fettuccine Pasta, garnished with fresh parsley. Save
A close-up view of the rich, enticing Cajun Chicken Alfredo Fettuccine Pasta, garnished with fresh parsley. | ovenharmony.com

My family loves gathering around the table to enjoy this flavorful pasta, especially on busy weeknights.

Required Tools

Large pot, Large skillet, Knife and cutting board, Tongs or pasta fork, Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter). Contains wheat (fettuccine). Contains chicken. Those with allergies should check ingredient labels for hidden allergens.

Nutritional Information

Calories: 670 Total Fat: 32 g Carbohydrates: 57 g Protein: 41 g per serving.

Imagine the aroma: Spicy Cajun chicken atop perfectly sauced Cajun Chicken Alfredo Fettuccine Pasta, a comforting feast. Save
Imagine the aroma: Spicy Cajun chicken atop perfectly sauced Cajun Chicken Alfredo Fettuccine Pasta, a comforting feast. | ovenharmony.com

This dish delivers rich creamy flavor with a spicy kick perfect for a comforting meal.

Cajun Chicken Alfredo Pasta

Tender Cajun chicken with creamy Velveeta sauce and fettuccine creates a rich, comforting Southern-style dish.

Prep duration
15 min
Cook duration
25 min
Complete duration
40 min
Created by Claire Johnson

Classification Easy Weeknight Meals

Complexity Easy

Heritage American (Cajun-inspired)

Output 4 Portions

Dietary considerations None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 ounces Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Directions

Phase 01

Cook Fettuccine: Bring a large pot of salted water to a boil. Cook fettuccine according to package directions until al dente. Drain and reserve ½ cup of pasta water.

Phase 02

Prepare Chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning on both sides.

Phase 03

Sear Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden and internal temperature reaches 165°F. Remove from skillet and let rest 5 minutes before slicing thinly.

Phase 04

Sauté Garlic: Reduce heat to medium. In the same skillet, melt butter and sauté minced garlic for 1 minute until fragrant.

Phase 05

Create Sauce Base: Add heavy cream to skillet and bring to a gentle simmer. Stir in Velveeta cubes, stirring constantly until melted and smooth.

Phase 06

Finish Sauce: Mix in Parmesan cheese, black pepper, cayenne pepper if using, and salt to taste. Adjust thickness by gradually adding reserved pasta water until creamy consistency is achieved.

Phase 07

Combine Pasta and Sauce: Toss cooked fettuccine in the sauce until thoroughly coated.

Phase 08

Serve: Plate pasta and top with sliced Cajun chicken. Garnish with chopped parsley and additional Parmesan cheese if desired.

Necessary tools

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy details

Review each component for potential allergens and consult healthcare professionals if you're unsure about ingredients.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat/gluten (fettuccine pasta)
  • Contains poultry (chicken)

Nutritional information (each portion)

These values are approximate guidelines only and shouldn't replace professional medical guidance.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g